The protagonist is the primary character in a story, or the playable character in a video game. While a story can have multiple main characters, the protagonist is the focus of the plot. (The equivalent characters in the role-plays are primary characters.)
James Zanasiu is considered the main character of the Darwin's Soldiers role-plays, while his Furtopia counterpart is the protagonist of Darwin's Soldiers (Furtopia). Dr. Jan Orlich is the main character of the reboot and James Zanasiu Jr is the main character of Chasing Seconds.
| Game | Protagonist |
| Find the Cure! | The Traveler |
| Gamer 2 | Hailey |